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Urology - Catheters

Silicone balloon catheters for transurethral, suprapubic and nephrostomy use with and without UroNova coating were tested clinically in cross-over studies.

Left: Uncoated silicone nephrostomy balloon catheter after 2 weeks indwelling time. Complete blockage by encrustation.
Right: Silicone nephrostomy balloon catheter with UroNova coating after 6 weeks indwelling time, in the same patient. No significant deposits.
UroNova medical device stent catheter coating encrustation infection bacteria antimicrobial antibacterial clinical operational financial benefits
UroNova medical device stent catheter coating encrustation infection bacteria antimicrobial antibacterial clinical operational financial benefits
From: Tenke et al., Int J of Antimicrob Agents, 2004 (23)

An average maximum indwelling time of 85.1 days with coated transurethral silicone balloon catheters versus 27.7 days with uncoated transurethral silicone balloon catheters was proven in a clinical cross-over setting with 5753 catheter days.

Below: 3.1 times longer indwelling time with UroNova coating on transurethral silicone balloon catheters. Indwelling times in days.
UroNova medical device stent catheter coating encrustation infection bacteria antimicrobial antibacterial clinical operational financial benefits
Data on file.

Nephrostomy tubes with UroNova coating are more expensive than standard catheters. However, with longer indwelling times and reduction of the number of exchange procedures, the total costs for coated nephrostomy tubes should be reduced compared to other catheters.

Below: Costs per year for nephrostomy tubes with UroNova coating and uncoated silicone catheters
UroNova medical device stent catheter coating encrustation infection bacteria antimicrobial antibacterial clinical operational financial benefits
Data on file.

In vitro experiments with Gram positive & negative, coagulase positive & negative and urease positive bacteria with concentrations of 1.5 million CFU/ml have shown a significant reduction of bacterial adherence on silicone material with UroNova coating compared to uncoated silicone.
UroNova medical device stent catheter coating encrustation infection bacteria antimicrobial antibacterial clinical operational financial benefits
From: Hildebrandt et al., Biomed Tech, 2002 (47)
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